Effect of dietary sodium bicarbonate supplementation on the toxicokinetics of ochratoxin A in pigs |
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Authors: | R Blank S Wolffram |
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Institution: | (1) Institute of Animal Nutrition and Physiology, Christian-Albrechts-University, D-24098 Kiel |
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Abstract: | The mycotoxin ochratoxin A (OA) is regarded as a causative agent for endemic nephropathy in farm animals and humans. Reabsorption
of OA along the nephron results from nonionic diffusion and by carrier-mediated mechanisms indicating that urine alkalinization
may help to accelerate OA excretion and thus reduce its toxicity. The aim of the present study was to investigate the effect
of a dietary sodium bicarbonate (NaHCO3) supplementation as a means to increase urinary pH on the systemic availability and excretion of OA in pigs. Dietary supplementation
of 2% NaHCO3 increased urinary pH (5.7±0.2 to 8.3±0.1) and daily urine volume (1108±276 to 2479±912ml) significantly. The systemic availability
of OA and its dechloro-analog Ochratoxin B (OB) in the NaHCO3 group calculated as the area under the serum concentration-time curve (AUC) was reduced to 75 and 68%, respectively, of the
control (P<0.05). This effect was mainly due to an accelerated elimination of OA and OB in the urine. The faster renal elimination
might be explained by a reduced reabsorption of the ochratoxins by nonionic diffusion, and other H+-dependent mechanisms. Thus, urinary alkalinization might be an efficient means to partially reduce the toxic effects and
carry-over of OA in pigs.
Presented at the 26th Mykotoxin Workshop in Herrsching, Germany, May 17–19, 2004 |
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Keywords: | bioavailability excretion ochratoxin A ochratoxin B |
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