Projections and actions of tachykininergic, cholinergic, and serotonergic neurones in the intestine of the Atlantic cod |
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Authors: | P Karila Fatemeh Shahbazi Jörgen Jensen Susanne Holmgren |
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Institution: | Department of Zoophysiology, G?teborg University, Medicinaregatan 18, S-41390 G?teborg, Sweden, SE
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Abstract: | The native tachykinins cod neurokinin A and cod substance P, serotonin and acetylcholine have excitatory effects on the circular
smooth muscle of the cod intestine. Furthermore, immunoreactivities to the cod tachykinins, serotonin and two markers for
cholinergic neurones, viz. choline acetyltransferase and vesicular acetylcholine transporter, have been demonstrated in myenteric
neurones of the cod intestine. In order to elucidate whether the neurones containing these substances project orally and thus
might be involved in the ascending excitatory reflex of peristalsis, myotomy operations have been performed on the cod intestine.
The immunoreactive areas of the myenteric plexus immediately oral and anal to the myotomy operations have been measured by
using confocal laser scanning microscopy. Large accumulations of immunoreactivity to the tachykinins are found on the anal
side of the myotomies, indicating oral projections of tachykininergic neurones. The areas immunoreactive to serotonin and
choline acetyltransferase are of equal size on the oral and anal sides. Since the tachykinin containing neurones of the intestine
project orally, and since cod neurokinin A and cod substance P have excitatory effects on circular smooth muscle, we conclude
that tachykininergic neurones are involved in the ascending excitatory reflex of peristalsis in the cod intestine.
Received: 6 March 1997 / Accepted: 15 September 1997 |
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Keywords: | Nervous system enteric Substance P Choline acetyltransferase Vesicular acetylcholine transporter Serotonin Myotomy Gadus morhua (Teleostei) |
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