Selenium deficiency-induced alterations in the vascular system of the rat |
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Authors: | Xianghu Qu Kaixun Huang Liqun Deng Huibi Xu |
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Affiliation: | (1) Department of Chemistry, Huazhong University of Science and Technology, 430074 Wuhan, People’s Republic of China |
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Abstract: | To enunciate the mechanisms whereby Se protects against cardiovascular diseases, weanling male Wistar rats were fed deficient (0.022 mg/kg diet) and adequate (0.159 mg/kg diet) Se diets for 14 and/or 39 wk. As the Se content and glutathione peroxidase activity were decreased and the lipid peroxide level was increased, the plasma 6-keto-PGF1α concentration of the Se-deficient group was markedly decreased in blood and tissues of the Se-deficient rats, as compared with the Se-adequate animals. Furthermore, the Se-deficient group had significantly lower plasma nitric oxide content and vascular nitric oxide synthase activity, higher erythrocyte sedimentation equation K value and aggregation index, and lower erythrocyte deformability than the Se-adequate group. Experimental Se deficiency also resulted in significant increases in serum total cholesterol and low-density lipoprotein cholesterol levels and a significant decrease in serum high-density lipoprotein cholesterol level. These results give some experimental supports to the hypothesis that low Se status and lipid peroxidation are involved in the etiology of cardiovascular diseases. |
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Keywords: | Selenium vascular system glutathione peroxidase lipid peroxide prostacyclin nitric oxide lipoproteins hemorheology |
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