On the integration of subthreshold inputs from Perforant Path and Schaffer Collaterals in hippocampal CA1 pyramidal neurons |
| |
Authors: | Migliore Michele |
| |
Institution: | (1) Section of Neurobiology, Yale University School of Medicine, New Haven, CT, USA;(2) Nat. Res. Council, Institute of Biophysics, Palermo, Italy |
| |
Abstract: | Using a realistic model of a CA1 hippocampal pyramidal neuron, we make experimentally testable predictions on the roles of the non-specific cation current, I
h
, and the A-type Potassium current, I
A
, in modulating the temporal window for the integration of the two main excitatory afferent pathways of a CA1 neuron, the Schaffer Collaterals and the Perforant Path. The model shows that the experimentally observed increase in the dendritic density of I
h
and I
A
could have a major role in constraining the temporal integration window for these inputs, in such a way that a somatic action potential (AP) is elicited only when they are activated with a relative latency consistent with the anatomical arrangement of the hippocampal circuitry. |
| |
Keywords: | dendritic integration I
A
I
h
CA1 modeling |
本文献已被 PubMed SpringerLink 等数据库收录! |
|