α-螺旋型抗菌肽结构参数与功能活性的关系

随着耐药病原菌出现，寻求更为安全有效的新型抗菌制剂迫在眉睫。抗菌肽具有广谱抗菌活性，杀菌快，不易产生耐药性等优点，是理想的新型抗菌剂，具有广阔前景。α-螺旋型抗菌肽是抗菌肽中的一大类。本文从α-螺旋型抗菌肽螺旋度，疏水力矩，疏水性，净正电荷数等方面阐述了结构与功能关系，及构效关系在α-螺旋抗菌肽分子设计与改造中的应用。

The structural parameters-functional activity relationship of alpha-helical antimicrobial peptides

In response to problems from the development of multi-drug-resistant pathogenic bacteria,it is urgent to find new antimicrobials.Antimicrobial peptides(AMPs) are a kind of ideal new antimicrobials with the advantages including their potential for broad-spectrum activity,rapid bactericidal activity and low propensity for resistance development,and have a bright future.Alpha-helical antimicrobial peptides are a main kind of AMPs.The following features was reviewed and elucidated including the structure and activity relationship(SAR) from different aspects including the degree of helicity,hydrophobic moment,hydrophobicity,net positive charges and so on,and the application of SAR on the molecular design and improvement of AMPs.