Neural Transplantation for Parkinson's Disease |
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Authors: | Isao Date Takashi Ohmoto |
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Affiliation: | (1) Department of Neurological Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, 700, Japan |
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Abstract: | 1. Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative source.2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain.3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described. |
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Keywords: | neural transplantation Parkinson's disease dopamine adrenal medulla chromaffin cell cryopreservation encapsulated cell grafting |
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