Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents |
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| Authors: | Shin Dae-Seop Kim Jiin Han Dong Cho Son Kwang-Hee Lee Chang Woo Kim Hwan-Mook Hong Su Hyung Kwon Byoung-Mog |
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| Institution: | Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Daejeon 305-333, Republic of Korea. |
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| Abstract: | A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis. |
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