| 微针及其在生物诊疗中的应用研究进展 |
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| 引用本文： | 刘天琦,宋高,曾志勇,张雪雅,张敏青,江国华. 微针及其在生物诊疗中的应用研究进展[J]. 生物工程学报, 2021, 37(4): 1139-1154 |
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| 作者姓名： | 刘天琦 宋高 曾志勇 张雪雅 张敏青 江国华 |
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| 作者单位： | 1 浙江理工大学 材料科学与工程学院，浙江 杭州 310018;2 浙江理工大学 智能生物材料研究所，浙江 杭州 310018;4 浙江理工大学 体育教研部，浙江 杭州 310018;1 浙江理工大学 材料科学与工程学院，浙江 杭州 310018;2 浙江理工大学 智能生物材料研究所，浙江 杭州 310018;3 浙江-毛里求斯生物医用材料与组织工程联合中心，浙江 杭州 310018 |
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| 基金项目： | 国家自然科学基金 (Nos. 51873194, 51373155)，浙江省自然科学基金 (No. LY18E030006) 资助。 |
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| 摘 要： | 微针在过去几十年中发展迅速,在透皮给药等领域已得到了广泛的研究.近些年随着微电子技术的蓬勃兴起,微针在生物诊疗中的应用越来越多的受到人们关注.通过微针提取血液和组织液进行检测分析以及微针作为电极在体液内直接对血糖、黑色素瘤、pH值等进行实时检测方面,都展现出了良好的实时检测应用前景.文中综述了微针的材料与结构设计及其在...
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| 关 键 词： | 微针 可穿戴设备 实时检测 微创 无痛 |
| 收稿时间： | 2020-06-20 |
Microneedles in diagnosis and treatment: a review |
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| Tianqi Liu,Gao Song,Zhiyong Zeng,Xueya Zhang,Minqing Zhang,Guohua Jiang. Microneedles in diagnosis and treatment: a review[J]. Chinese journal of biotechnology, 2021, 37(4): 1139-1154 |
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| Authors: | Tianqi Liu Gao Song Zhiyong Zeng Xueya Zhang Minqing Zhang Guohua Jiang |
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| Affiliation: | 1 College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China;2 Institute of Smart Biomaterials, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China;4 Department of PE, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China; 1 College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China;2 Institute of Smart Biomaterials, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China;3 Zhejiang Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China |
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| Abstract: | Microneedles have been developed rapidly in the field of transdermal administration in the past few decades. In recent years, the development of microelectronics technology has expanded the applications of microneedles by combining with microelectronic systems, especially in biological diagnosis and treatment. Different types of microneedles have been designed to extract blood and tissue fluids for detection, or as electrodes to directly detect blood sugar, melanoma and pH in real-time in vivo, both show good prospects for real-time detection applications. In this paper, we review the design of materials and structure of microelectronic-based microneedles, and discuss their advances in biological diagnosis. |
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| Keywords: | microneedle wearable device real-time detection minimally invasive painless |
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