Detoxification of amitriptyline by oligochitosan derivatives |
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Authors: | Dong-Won Lee Ronald Baney |
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Affiliation: | Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA. |
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Abstract: | Oligo-chitosans were chemically modified with dinitrophenyl groups for selective and rapid adsorption of amitriptyline by forming pi-pi complexes. 1H-NMR was utilized not only for characterization of modified chitosans but also for monitoring the aromatic-aromatic interaction. The variation in the chemical shift of aromatic protons was followed to monitor the aromatic-aromatic interaction. Upfield shift of aromatic protons of dinitrophenyl groups supports aromatic-aromatic interactions with amitriptyline. Drug uptake test by HPLC reveals that dinitrophenyl chitosan particles (1-2 microm) at 0.4 wt% (w/v) in a saline solution (pH 6.9) adsorb 90% amitriptyline within 30 min. |
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Keywords: | amitriptyline aromatic-aromatic interaction chemical shift chitosan HPLC |
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