Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism |
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Authors: | Kim Sanghee Kim Eunkyung Shin Dong Sun Kang Heonjoong Oh Ki Bong |
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Institution: | Natural Products Research Institute, Seoul National University, 28 Yungun, Jongro, 110-460, Seoul, Republic of Korea. pennkim@snu.ac.kr |
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Abstract: | A series of farnesoic acid derivatives was prepared and their morphogenic regulatory activities were evaluated. Their inhibitory activities against yeast cell growth and yeast-to-hypha transition examined in Candida albicans cells are dependent upon the chain length as well as the substitution patterns on the isoprenoid template. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements. |
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