An efficient method for the synthesis of [2-(15)N]guanosine and 2'-deoxy[2-(15)N]guanosine derivatives. |
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| Authors: | K Kamaike K Kinoshita K Niwa K Hirose K Suzuki Y Ishido |
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| Institution: | Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. |
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| Abstract: | Nucleophilic substitution reaction of 6-chloro-2-fluoro-9-beta-D-ribofuranosyl-9H-purine derivative, prepared from guanosine, with potassium 15N]phthalimide at 40 degrees C for 9 h in DMF, followed by hydrolysis, afforded 2-(15)N]guanosine derivative efficiently. The corresponding 2'-deoxy derivative was also synthesized through a similar procedure. |
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