Regional localization and molecular characterization of a DNA sequence on the long arm of chromosome 22 |
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Authors: | Elisabeth Göttert Reinhold Metzdorf Uwe Färber Nikolaus Blin |
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Institution: | 1. Institut für Humangenetik, Universit?tsklinik, D-6650, Homburg/Saar, Federal Republic of Germany
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Abstract: | Summary A human genomic DNA fragment, p22hom13 (D22S16), was isolated from a chromosome 22-specific library. After elimination of
repetitive sequences, a single copy BamHI-EcoRI fragment was subcloned into pTZ18. By using mouse/human somatic cell hybrids and in situ hybridization, the new DNA probe
was mapped to chromosome 22q13-qter. Its application in the analysis of the distal part of chromosome 22 and its diagnostic
use in translocations are discussed. |
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