Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B |
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| Authors: | W R Bensch T S Ingebritsen E R Diller |
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| Institution: | 1. Laboratory of Nuclear Medicine and Radiation Biology, School of Medicine University of California, Los Angeles, California 90024 USA;2. Department of Biological Chemistry, School of Medicine University of California, Los Angeles, California 90024 USA |
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| Abstract: | The phospholipase-2 inhibitor, p-bromophenacyl bromide, has been shown to inhibit strongly the elongation of endogenous fatty acids in preparations of brain mitochondria and microsomes. On the other hand, it does not inhibit the elongation of added palmitic or linoleic acids. The implication is that the normal first step in alteration of membrane lipid fatty acids is their release to other membrane-bound enzyme systems by a membrane-bound phospholipase A. |
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