Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells |
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Authors: | Chandra Abhishek Itakura Tatsuo Yang Zhi Tamakoshi Tomoki Xue XiaoDong Wang Bo Ueki Takatoshi Sato Kohji Uezato Tadayoshi Miura Naoyuki |
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Affiliation: | Department of Biochemistry, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan. |
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Abstract: | Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously isolated the Neurogenesin-1 (Ng1) gene and found that Ng1 protein induces neuronal differentiation in the brain. In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. Interestingly, Ng1 protein inhibited the BMP7-induced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. All data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs. |
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Keywords: | BMP BMP antagonist Neurogenesin-1 Osteoblast Differentiation Alkaline phosphatase |
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