Dynamics of Cytokine/Chemokine Responses in Intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection |
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| Authors: | Carys S Kenway-Lynch Arpita Das Diganta Pan Andrew A Lackner Bapi Pahar |
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| Institution: | Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USAa;Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USAb;Tulane University School of Medicine, New Orleans, Louisiana, USAc |
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| Abstract: | Loss of intestinal CD4+ T cells was associated with decreased production of several T-helper 1 (TH1) and TH2 cytokines and increased production of interleukin 17 (IL-17), gamma interferon (IFN-γ), CCL4, and granulocyte-macrophage colony-stimulating factor (GM-CSF) by CD8+ T cells 21 days after simian immunodeficiency virus (SIV) infection in rhesus macaques. Shifting of mucosal TH1 to TH2 or T-cytotoxic 1 (TC1) to TC2 cytokine profiles was not evident. Additionally, both CD4+ and CD8+ T cells showed upregulation of macrophage migration inhibition factor (MIF) and basic fibroblast growth factor (FGF-basic) cytokines that have been linked to HIV disease progression. |
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