Latency Locus Complements MicroRNA 155 Deficiency In Vivo |
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| Authors: | Sang-Hoon Sin Yong Baek Kim Dirk P. Dittmer |
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| Affiliation: | Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAa;Department of Veterinary Medicine, College of Veterinary Medicine, Seoul National University, Seoul, South Koreab |
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| Abstract: | MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi''s sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer''s patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155. |
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