Transient Compartmentalization of Simian Immunodeficiency Virus Variants in the Breast Milk of African Green Monkeys |
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| Authors: | Carrie Ho Steven Wu Joshua D Amos Lisa Colvin Shannon D Smith Andrew B Wilks C Todd DeMarco Christie Brinkley Thomas N Denny Joern E Schmitz Allen G Rodrigo Sallie R Permar |
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| Institution: | Human Vaccine Institutea;Division of Laboratory Animal Resources,b Duke University Medical Center, Durham, North Carolina, USA;Department of Biology, Duke University, Durham, North Carolina, USAc;Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USAd |
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| Abstract: | Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally. |
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