Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis |
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| Authors: | Rajasri Bhattacharyya Misha Shukla Sachin Nagra Dibyajyoti Banerjee |
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| Affiliation: | 1.Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India;;2.Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; |
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| Abstract: | Diabetes mellitus is considered as a predisposition factor for active tuberculosis and is known to activate the latent form oftuberculosis. However, the causative association of latent tuberculosis with diabetes is not conclusively established. Therefore, it isof interest to relate their predisposition. We describe the glycation pattern of mescenchymal stem cell surface markers asCD271+/CD45-mescenchymal stem cell is known to be associated with latent tuberculosis. We show that the lysine residuesimportant for function of CD271 death domain are predicted to be and glycated. These observations help to discuss the role ofCD271 and glycation to modulate the genesis of latent tuberculosis in chronic diabetic mellitus. |
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| Keywords: | Diabetes Mellitus active tuberculosis latent tuberculosis mesenchymal stem cell markers glycation |
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