Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis |
| |
Authors: | V E Kelley G N Gaulton M Hattori H Ikegami G Eisenbarth T B Strom |
| |
Institution: | Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Boston, MA 02115. |
| |
Abstract: | In order to assess the importance of interleukin 2 receptor (IL-2R)-positive activated lymphocytes and macrophages in the pathogenesis of autoimmunity, we tested the prophylactic therapeutic efficacy of an anti-IL-2R (M7/20) monoclonal antibody, which recognizes the 55-kDa subunit of the heterodimeric IL-2R in two distinct models: the nonobese diabetic mouse and the NZB x NZW F1 hybrid with lupus. Treatment with anti-IL-2R monoclonal antibody suppressed autoimmune insulitis in nonobese diabetic mice and lupus nephritis in the NZB x NZW F1 hybrid. These studies indicate that highly selective targeting to activated lymphocytes and macrophages expressing the IL-2R provides a discrete method of dampening autoimmunity. |
| |
Keywords: | |
|
|