Effect of sodium butyrate on the hepatoma cell cycle: Possible use for cell synchronization |
| |
Authors: | Roeland van Wijk Lydie Tichonicky Jaques Kruh |
| |
Institution: | (1) Department of Molecular Cell Biology, State University, Padualaan 8, 3584 CH Utrecht, The Netherlands;(2) Institut de Pathologie Moléculaire, Unité INSERM U 137, Centre Universitaire Cochin, 24 Rue de Faubourg Saint-Jaques, 75014 Paris, France |
| |
Abstract: | Summary Exposure of HTC cells to sodium butyrate caused inhibition of growth. The site of growth inhibition was studied by time-lapse
cinematography and 3H]thymidine incorporation studies. Evidence is presented that sodiunm butyrate affected the cell cycle at a specific point
immediately after mitosis. Inasmuch as it does not modify the interphase duration after its removal, butyrate may be used
for HTC synchronization.
This work was supported by l'Institut Nationale de la Santé et de la Recherche Médicale and la Centre Nationale de la Recherche
Scientifique (L. T. and J. K.). |
| |
Keywords: | rat hepatoma cells butyric acid growth regulation |
本文献已被 SpringerLink 等数据库收录! |
|