Cloning,expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9) |
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Authors: | Wang Shu Zhang Zhen Ying Kang Chen Jin-zhong Meng Xian-fang Yang Quan-Sheng Xie Yi Mao Yu-min |
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Affiliation: | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People's Republic of China. |
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Abstract: | During a large-scale screen of a human fetal brain cDNA library, a full-length cDNA encoding a novel Rap2 interacting protein was isolated and sequenced. The cDNA is 3397 bp long and has a predicted open reading frame encoding a protein of 329 aa. The predicted protein shows high homology to mouse and human RPIP8, and has a RUN domain near its C-terminus. The gene was mapped to human chromosome 7q21–7q22 and has 9 exons and 8 introns. The expression pattern was also detected by cycle-limited reverse polymerase chain reaction (RT-PCR). |
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Keywords: | Ras GEF RPIP9 RT-PCR chromosome 7q21– 7q22 |
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