PTH and PTHrP signaling in osteoblasts |
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Authors: | Nabanita S Datta Abdul B Abou-Samra |
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Institution: | 1. Gerontology Section, Department of Medical Science, University of Torino, Italy;2. Unit of Cancer Epidemiology, Department of Medical Science, University of Torino, Italy |
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Abstract: | The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function. |
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