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Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss |
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| Authors: | Ilaria Bellantuono Abdullah Aldahmash Moustapha Kassem |
| Affiliation: | 1. Academic Unit of Bone Biology, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK;2. Stem Cell Unit, Department of Anatomy, King Saud University, Riyadh, Saudi Arabia;3. University Department of Endocrinology, University Hospital of Odense & Medical Biotechnology Center, Winslowsparken 25, DK-5000 Odense, Denmark |
| Abstract: | Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention. |
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