Protein interaction with hydrated C60 fullerene in aqueous solutions |
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| Authors: | Rozhkov S P Goryunov A S Sukhanova G A Borisova A G Rozhkova N N Andrievsky G V |
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| Institution: | Institute of Biology, Karelian Research Center, RAS, 185610 Petrozavodsk, Russia. rozhkov@krc.karelia.ru |
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| Abstract: | Physicochemical effects of hydrated C(60) fullerenes (HyFn) on serum albumin molecules were studied using ESR spin labeling and differential scanning microcalorimetry. Molecular-colloidal solution of hydrated C(60) fullerenes and their small spherical fractal clusters in water (C(60)FWS), was shown to stabilize protein hydration, and decrease specific surface energy in water-protein matrix in salt solutions. The mechanism of HyFn interaction with protein is discussed in terms of HyFn induced formation of protein clusters and phase transition of hydration water. |
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| Keywords: | Protein Fullerene Interaction Spin label Microcalorimetry Clusters Surface energy Phase transition |
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