Long-lasting effects of chronic ethanol administration on the activity of antioxidant enzymes |
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Authors: | VÎnia D' Almeida Maristela Goldnadel Monteiro Maria Gabriela M Oliveira Ana Cristina Pomarico Orlando Francisco Amodeo Bueno Maria Eugnia da Silva-Fernandes |
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Institution: | Vǎnia D' Almeida,Maristela Goldnadel Monteiro,Maria Gabriela M. Oliveira,Ana Cristina Pomarico,Orlando Francisco Amodeo Bueno,Maria Eugěnia da Silva-Fernandes |
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Abstract: | The aim of this study was to investigate the long-lasting effects of prolonged administration of ethanol doses on oxidative processes of aged rats. We determined the activity of superox-ide dismutase (SOD), catalase (CAT), and gluta-thione peroxidase (GPx) in erythrocytes of rats 15, 20, and 24 months old treated with an average daily dose of 1.5 g/Kg of ethanol or saline administered intraperitoneally for 13 weeks and after a 2 month period of withdrawal from treatment. The activity of all three enzymes decreased significantly with aging in the controls, while no age-related changes were found among treated rats. These findings are important since they are the first to show a long-lasting toxic effect of low ethanol doses observed in association with the aging process. |
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Keywords: | Alcohol Aging Antioxidant Enzymes Long-Lasting Effect |
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