Preparation of 5-alkyltetrahydrofolic acids (dl-5-alkyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acids) |
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| Authors: | J A Blair K J Saunders |
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| Affiliation: | 1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States;2. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States;3. Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, United States;1. Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan;2. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan;3. Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan;1. Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada;2. Department of Pediatrics, University of Virginia, Charlottesville, VA, USA;3. Department of Biology, University of Virginia, Charlottesville, VA, USA;4. W. M. Keck Center for Cellular Imaging, Department of Biology, University of Virginia, Charlottesville, VA, USA;1. Department of Medicinal Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China;2. Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China;1. Univ Lyon, Université Claude Bernard Lyon 1, ISPB-Faculté de Pharmacie, EA 4446, B2MC, F-69373, Lyon Cedex 08, France;2. Univ Lyon, Université Claude Bernard Lyon 1, VetAgro Sup, UMR CNRS 5557, Ecologie Microbienne, F-69622, Villeurbanne, France;3. Laboratoire de Bactériologie, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon (HCL), F-69, Bron, France;1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States;2. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 421 E. Canfield Street, Detroit, MI 48201, United States;3. Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States;4. Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, United States |
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| Abstract: | The ethyl, n-propyl, and n-butyltetrahydrofolic acids have been prepared as their calcium salts by a method similar to that for 5-methyl-tetrahydrofolic acid. |
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