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Engineered T cells for cancer therapy |
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| Authors: | Carl H. June Marcela V. Maus Gabriela Plesa Laura A. Johnson Yangbing Zhao Bruce L. Levine Stephan A. Grupp David L. Porter |
| Affiliation: | 1. Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, 8th Floor, Philadelphia, PA, 19104-5156, USA 4. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3. Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA |
| Abstract: | It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused research review. |
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