Myo-inositol transport in the small intestine of the domestic fowl |
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| Affiliation: | 1. Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA;2. Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, 75185 Uppsala, Sweden;1. Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria;2. BioTechMed-Graz, 8010 Graz, Austria;3. Field of Excellence BioHealth, University of Graz, 8010 Graz, Austria;4. Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria;5. Department of Anatomy and Histology, University of Veterinary Medicine Budapest, 1078 Budapest, Hungary;6. Veneto Institute of Molecular Medicine, 35129 Padova, Italy;7. Research Center for Child Mental Development, University of Fukui, 910-1193 Fukui, Japan;8. Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging Molecular Biology and Biochemistry Medical University of Graz, 8010 Graz, Austria;9. Otto Loewi Research Center (for Vascular Biology, Immunology and Inflammation), Division of Pharmacology, Medical University of Graz (MUG), 8010 Graz, Austria;10. Department of Neurosurgery, RU Experimental Neurotraumatology, Medical University Graz, 8036 Graz, Austria;11. Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland;12. Department of Psychiatry, Bruneck Hospital, 39031 Bruneck, Italy;13. Department of Neurology, Bruneck Hospital, 39031 Bruneck, Italy;14. Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, 6020 Innsbruck, Austria;15. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical University of Innsbruck, 6020 Innsbruck, Austria;16. Department of Psychiatry and Psychotherapy A, Hall State Hospital, 6060 Hall in Tirol, Austria;17. HEALTH-Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft mbH, 8010 Graz, Austria;18. Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria;19. Equipe Labellisée par la Ligue Contre le Cancer, Université Paris Descartes, Université Paris Diderot, Université Sorbonne Paris Cité, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France;20. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94 805 Villejuif, France;21. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France;22. Suzhou Institute for Systems Biology, Chinese Academy of Sciences, 215123 Suzhou, China;23. Department of Women’s and Children’s Health, Karolinska University Hospital, 171 77 Stockholm, Sweden;24. Department of Cardiology, Medical University of Graz, 8036 Graz, Austria;25. Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia;26. Institute of Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany;27. VASCage, Research Centre on Vascular Ageing and Stroke, 6020 Innsbruck, Austria;28. Department of Biology, University of Padova, 35121 Padova, Italy;1. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, 199 Ren’ai Road, Suzhou 215123, PR China;2. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, PR China;3. Collaborative Innovation Center of Radiological Medicine of Jiangsu, Higher Education Institutions, Soochow University, Suzhou 215123, PR China;1. Pharmaceutical Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;2. Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Pharmacogenosy, Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;4. Gholampour Psychiatric Clinic, Mohtashami Avenue, Mashhad, Iran;5. Neurogenic Inflammation Research Center, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth, Australia;1. Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland;2. APC Microbiome Ireland, University College Cork, Cork, Ireland;3. Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland;4. Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland |
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| Abstract: | - 1.1. Myo-inositol is transported in chicken small intestine by a mediated route with an apparent Km of 0.1 mM and by a diffusion mechanism.
- 2.2. The mediated route is susceptible to inhibition by sugars, though sugars are not transported by this process, nor is myo-inositol transported by the sugar transport system.
- 3.3. Myo-inositol influx is inhibitable by phlorizin, sulfhydryl reagents, removal of Na+ from the incubation medium, and preloaded sugar; it can be stimulated by theophylline.
- 4.4. The ability to absorb this nutrient varies greatly between individual animals.
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