The effects of a saluretic (Lasix) on adrenal steroidogenesis in the echidna (Tachyglossus aculeatus) |
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| Affiliation: | 1. LURPA, ENS Cachan, University Paris-Sud, Universite Paris-Saclay, 94235 Cachan, France;2. Daniel J. Epstein Department of Industrial and Systems Engineering, University of Southern California, Los Angeles, CA 90089, USA;1. PG & Research Department of Physics, Arignar Anna Govt. Arts College, Cheyyar 604 407, India;2. Department of Physics / R&D, Edayathangudy G.S Pillay Arts and Science College, Nagapattinam 611 002, India;3. PG & Research Department of Chemistry, Arignar Anna Govt. Arts College, Cheyyar 604 407, India;4. Department of Physics, Thirumalai Engineering College, Kilambi, Kanchipuram 631 551, India;5. PG & Research Department of Physics, The New College, Chennai 600 014, India;1. School of Engineering, RMIT University, Melbourne, Victoria, 3001, Australia;2. Honorary Principal in Plant Science and Arboriculture, Burnley College, University of Melbourne, Melbourne, Victoria, 3021, Australia;1. Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt;2. Department of Biochemistry, Faculty of Pharmacy, October 6 University, Cairo, Egypt |
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| Abstract: | 1. Metabolic turnover studies during 7 days Lasix administration showed a water and sodium loss which sustained for 3 days, potassium was unaffected.2. Adrenal homogenates from treated echidnas converted 14C progesterone to cortisol, corticosterone, aldosterone, 11-deoxycortisol and 11-deoxycorticosterone in yields of ; 6 ± 0.2, 46 ± 4, 0.3 ± 0.1, 8 ± 2 and 13 ± 5% (mean ± SEM) respectively.3. Compared to controls, cortisol, corticosterone and aldosterone increasedby factors of 12, 7 and 15 respectively.4. The peripheral blood aldosterone was, in Lasix treated echidnas 44 ng/100 ml a 5-fold increase.5. The Km and V for 11β-hydroxylation of 11-deoxycorticosterone were 35 μM and 9 ϱmol/min/mg. the V increase being 3-fold. |
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