Mucus as a diffusion barrier to oxygen: Possible role in O2 uptake at low pH in carp (Cyprinus carpio) gills |
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| Affiliation: | 1. Abteilung Physiologie, Max Planck Institute for Experimental Medicine, Gottingen, W. Germany;2. Institute for Physiology, University of Regensburg, 8400 Regensburg, W. Germany;1. Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, 27519, Chapel Hill, NC, USA;2. UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina-Chapel Hill, 27519, Chapel Hill, NC, USA;3. Mapp Biopharmaceutical Inc, 92121, San Diego, CA, USA;4. Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;5. Institute for Genome Sciences, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;1. MTA-ÖK BLI NAP_B Adaptive Neuroethology, Department of Experimental Zoology, Balaton Limnological Institute, MTA Center for Ecological Research, Tihany, Hungary;2. Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, WA, District of Columbia 20052, USA;3. MTA-ÖK BLI, Department of Experimental Zoology, Balaton Limnological Institute, MTA Center for Ecological Research, Tihany, Hungary;1. NaWiTec, Thermal Process Engineering, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany;2. Fluid Dynamics and Technical Flow, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany |
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| Abstract: | - 1.1. The standard Vo2 of carp (Cyprinus carpio) is reduced at low pH, concurrently with the formation of mucus on the gills.
- 2.2. The rate of diffusion of oxygen through mucus produced by carp in response to low pH was measured in a diffusion chamber and found to be 2.60 × 10−5 cm2/min per atm. The diffusion constant for water measured with the same apparatus was 3.60 × 10−5cm2/min per atm.
- 3.3. The inhibition of the diffusion of oxygen into the gill bloodstream, and the inhibition of the flow of respiratory water between the secondary lamellae, are calculated for a gill with assumed dimensions. At thicknesses of mucus on the gills up to 5 μm the effects are similar, but at greater thicknesses the effect of slowing the water flow predominates. We conclude that mucus on the gills contributes to the hypoxia observed in fish subjected to high acidities.
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