Failure of beta-endorphin antiserum, naloxone, and naltrexone to alter physiologic growth hormone and insulin secretion. |
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Authors: | G S Tannenbaum A E Panerai H G Friesen |
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Institution: | 1. Departments of Pediatrics, and Neurology and Neurosurgery, McGill University (G.S.T.), Montreal, Quebec, France;2. Department of Physiology, University of Manitoba (A.E.P., H.G.F.), Winnipeg, Manotoba, USA |
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Abstract: | The role of endogenous opiate-like peptides in physiologic regulation of growth hormone (GH) and insulin (IRI) secretion was assessed by passive immunization with β-endorphin antiserum and by administration of the opiate antagonists naloxone and naltrexone. Six-hour secretory profiles were obtained from 5 groups of freely-moving chronically cannulated male rats following the i.v. administration of (I) β-endorphin antiserum, (II) normal rabbit serum, (III) naloxone (1 mg/kg), (IV) naltrexone (1 mg/kg), and (V) normal saline. The typical ultradian rhythm of GH secretion was evident in all groups with most peak GH values >400 ng/ml. No disruption in amplitude of periodicity of the GH rhythm was observed and there was no significant difference in mean 6-hr plasma GH levels. Plasma IRI levels fluctuated minimally over the 6-hr sampling period. There was no significant difference in mean 6-hr IRI levels between groups I and II, or between groups III, IV and V. These data do not support the view that endogenous opiate-like peptides play a physiologically important role in maintaining basal GH and IRI secretion. |
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Keywords: | Address requests for reprints: Dr Gloria S Tannebaum Department of Endocrinology Montreal Children's Hospital 2300 Tupper Street Montreal Quebec H3H 1P3 France |
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