Effect of small scale culture vessel type on hyphal fragment size and erythromycin production in Saccharopolyspora erythraea |
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| Authors: | ME Bushell GL Dunstan GC Wilson |
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| Institution: | (1) Microbial Products Laboratory, School of Biological Sciences, University of Surrey, Guildford Surrey, UK |
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| Abstract: | Erythromycin production dynamics in stirred, baffled shaken and non-baffled shaken flasks was strongly correlated with the different distributions of hyphal particle diameters observed. Production only took place when hyphal fragments with diameters greater than 88  m were observed. Results are consistent with significant hyphal breakage rates, even in non-baffled shaken flasks. |
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