Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models |
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| Authors: | Goel Atul Agarwal Nidhi Singh Fateh V Sharon Ashoke Tiwari Priti Dixit Manish Pratap Ramendra Srivastava Arvind K Maulik Prakas R Ram Vishnu J |
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| Affiliation: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India. agoel13@yahoo.com |
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| Abstract: | Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model. |
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