Characterization of neuritin as a novel angiogenic factor |
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Authors: | Han Dingding Qin Bo Liu Guoqing Liu Tingting Ji Guoqing Wu Yanhua Yu Long |
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Institution: | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China |
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Abstract: | Neuritin (NRN1), a neurotrophic factor, plays an important role in neurite growth and neuronal survival. In this study, we identify a new function of neuritin as a novel angiogenic factor in vitro and in vivo. Recombinant neuritin protein had no effect on the proliferation and adhesion of human umbilical vein endothelial cells (HUVEC), but it dose-dependently increased endothelial cell migration. Furthermore, overexpression of neuritin significantly promoted tumor angiogenesis, and surprisingly, it inhibited tumor growth in a xenograft tumor model. Thus, our results indicate that neuritin may act as an important angiogenic factor and serve as a potential target for cancer therapy. |
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Keywords: | Abbreviations: HUVEC human umbilical vein endothelial cell VEGF vascular endothelial growth factor PIGF placental growth factor FGF fibroblast growth factor PDGF platelet-derived growth factor CPG15 candidate plasticity-related gene 15 MVD microvessel density |
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