The association between the total antioxidant potential of plasma and the presence of coronary heart disease and renal dysfunction in patients with NIDDM |
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Authors: | Janne Leinonen Vappu Rantalaiho Terho Lehtimäki Timo Koivula Ole Wirta Amos Pasternack |
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Institution: | 1. Laboratory of Neurobiology, Medical School, University of Tampere, P.O. Box 607, 33101, Tampere, Finland;2. Research Laboratory for Atherosclerosis, Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland;3. Department of Internal Medicine, Tampere University Hospital, Tampere, Finland;4. Department of Medical Biochemistry, University of Tampere, Tampere, Finland;5. Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland |
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Abstract: | Oxidative stress may be an important pathogenetic factor in the development of diabetic vascular complications. The total antioxidative potential of plasma reflects the ability of an individual to resist oxidative stress. We measured the plasma total peroxyl radical-trapping potential (TRAP) and the concentrations of four plasma chain-breaking antioxidants in 81 patients with non-insulin-dependent diabetes mellitus (NIDDM) nine years after diagnosis and in 102 well-matched non-diabetic control subjects. The association between the total antioxidative potential and the presence of coronary heart disease (CHD) and diabetic kidney disease were also studied. There were no significant differences in plasma TRAP between NIDDM patients and control subjects (1250 ± 199 vs. 1224 ± 198 μM). Nor were there any significant differences in the concentrations of plasma uric acid, ascorbic acid, α-tocopherol, and protein thiols between NIDDM patients and control subjects. Patients with a low glomerular filtration rate and/or high urinary albumin excretion had elevated plasma uric acid. Plasma TRAP was not, however, associated with renal dysfunction. The plasma of NIDDM patients with CHD had a significantly higher value of unidentified antioxidative potential than that of patients without CHD. This relation was strongly dependent upon smoking. In conclusion, these data demonstrate that there are no major defects in the antioxidative potential of plasma caused by NIDDM per se. CHD and diabetic renal dysfunction were not associated with changes in plasma TRAP. |
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Keywords: | Diabetes mellitus non-insulin-dependent oxidative stress coronary disease antioxidants total peroxyl radical-trapping potential |
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