Fluidity and oxidative stress in erythrocytes from very low birth weight infants during their first 7 days of life |
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| Authors: | Dr Julio J. Ochoa Francisco Contreras-Chova Sergio Muñoz Eduardo Araujo-Nepomuceno Antonio Bonillo Antonio Molina-Carballo |
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| Affiliation: | 1. Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spainjjoh@ugr.es;3. Department of Pediatrics, ‘San Cecilio’ Universitary Hospital, Granada, Spain;4. Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain;5. Department of Pediatrics, ‘Torrecardenas’ Hospital, Almería, Spain |
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| Abstract: | Objective: To study the evolution of lipid peroxidation, enzymatic antioxidants response, lipid profile and membrane fluidity in erythrocytes from very low birth weight (VLBW) infants during their first 7 days of extra-uterine life.Study design: One hundred and twenty infants were selected and divided in two groups according to their weight and gestational age. Hydroperoxides, fatty-acid profile, fluidity (DPH and TMA-DPH) and catalase, SOD and GPx activities were measured in erythrocytes.Results: VLBW group showed higher concentration of hydroperoxides and lower membrane fluidity during the first 72 h, lower SOD activity during the first 3 h and higher GPx activity during the first 7 days of life. Also, this group showed lower n-3 polyunsaturated fatty-acids percentage with respect to the term group.Conclusion: Erythrocytes from VLBW infants showed higher oxidative damage and lower fluidity in their membranes, at least during the first 3 days of extra-uterine life, which may cause alterations in their functions and flexibility. |
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| Keywords: | Very low birth weight infants lipid peroxidation erythrocyte enzymatic antioxidant system fluidity fatty-acid profile |
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