Effect of C111T polymorphism in exon 9 of the catalase gene on blood catalase activity in different types of diabetes mellitus |
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| Authors: | I Tarnai M Csordás E Sükei A H Shemirani M Káplár |
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| Institution: | 1. Department of Clinical Analytical Chemistry, Medical and Health Science Center, University of Debrecen, Debrecen, H-4032, Hungary;2. Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, H-4032, Hungary;3. Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, H-4032, Hungary |
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| Abstract: | Hydrogen peroxide plays a major role in the pathomechanism of diabetes mellitus and its main regulator is enzyme catalase.The blood catalase and the C111T polymorphism in exon 9 was examined in type 1, type 2 and gestational diabetes mellitus.Compared to the control group (104.7 ± 18.5 MU/l) significantly decreased (p < 0.001) blood catalase activities were detected in type 2 (71.2 ± 14.6 MU/l), gestational (68.5 ± 12.2 MU/l) diabetes mellitus and without change in type 1 (102.5 ± 26.9 MU/l). The blood catalase decreased (p = 0.043) with age for type 2 diabetics and did not change (p>0.063) for type 1, gestational diabetic patients and controls. Blood catalase showed a weak association with hemoglobin A1c for type 1 diabetic patients (r = 0.181, increasing).The mutant T allele was increased in type 1 and gestational diabetes mellitus, and CT+TT genotypes showed decreased blood catalase activity for type 1 and increased activities for type 2 diabetic patients.The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus. |
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| Keywords: | Diabetes mellitus: type 1 type 2 gestational blood catalase C111T polymorphism in exon 9 mutation determination |
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