Changes of nitric oxide,carbon monoxide and oxidative stress in term infants at birth |
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| Authors: | Carlo Dani Lucia Giannini Giovanna Bertini Simone Pratesi Iuri Corsini Mariangela Longini |
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| Affiliation: | 1. Department of Surgical and Medical Critical Care, Section of Neonatology,cdani@unifi.it;3. Department of Clinical and Preclinical Pharmacology, Careggi University Hospital of Florence, Viale Morgagni, 85, 50134, Florence, Italy;4. Department of Surgical and Medical Critical Care, Section of Neonatology,;5. Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Viale M. Bracci, 16, 53100, Siena, Italy |
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| Abstract: | The higher risk of respiratory problem in infants delivered by elective caesarean section in comparison with vaginally born infants may be favoured by lower level of nitric oxide (NO) and carbon monoxide (CO) and higher oxidative stress in infants born by caesarean section. We studied healthy term infants born by vaginal delivery or by elective caesarean section. Nitric oxide, CO, guanosine 3–5 cyclic monophosphate, total hydroperoxide and advanced oxidation protein products (AOPP) were measured at birth and 48–72 h of life. Nitric oxide, CO and cGMP were lower at birth and at 48–72 h of life in infants born by elective caesarean delivery. Total hydroperoxide and AOPP levels were similar in the two groups and increased from birth to 48–72 h of life. In conclusion, nitric oxide and CO concentrations were higher in term infants vaginally born than in infants born by elective caesarean section and decreased from birth to 48–72 h of life. The mode of delivery did not affect the oxidative stress which increases from birth to 48–72 h of life. |
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| Keywords: | Nitric oxide carbon monoxide oxidative stress infant vaginal delivery caesarean section |
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