Integrative Action of Receptor Mosaics: Relevance of Receptor Topology and Allosteric Modulators |
| |
| Authors: | Agnati Luigi Francesco Guidolin Diego Genedani Susanna Woods S. Amina Ferrè Sergi |
| |
| Affiliation: | 1. Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy;2. Department of Anatomy and Physiology, University of Padova, Italy;3. National Institute on Drug Abuse, Intramural Research Program, NIH, Department of Health and Human Services, Baltimore, Maryland, USA |
| |
| Abstract: | After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders. |
| |
| Keywords: | Receptor mosaics Receptor topology Allosteric modulators Homocysteine |
|
|
