F2-Isoprostanes,tocopherols and normal pregnancy |
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Authors: | Maria Palm Ove Axelsson Lisa Wernroth |
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Affiliation: | 1. Department of Women's and Children's Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden;2. Uppsala Clinical Research Center, Uppsala, Sweden |
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Abstract: | This study investigates oxidative stress and antioxidants in normal human pregnancy and post-partum period. Thirty-seven healthy women with normal pregnancies were included. Both urinary and serum samples were collected throughout the pregnancy and post-partum period. Oxidative stress was estimated by measuring the reliable in vivo marker, namely 8-iso-prostaglandin F2α (8-iso-PGF2α, an F2-isoprostane) and antioxidant status was evaluated by measuring α- and γ-tocopherol in serum samples. Pregnancy was associated with successively increased levels of 8-iso-PGF2α with advancing gestational age. The median post-partum value corresponded to the values observed in early gestation and a significant decrease was observed from late pregnancy to the post-partum period. Lipid-adjusted α- and γ-tocopherol levels decreased with advancing gestational age. This longitudinal study suggests that mild oxidative stress is involved in normal human pregnancy. |
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Keywords: | Pregnancy free radicals oxidative stress antioxidants isoprostanes human |
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