Lack of effect of acute oral ingestion of vitamin C on oxidative stress,arterial stiffness or blood pressure in healthy subjects |
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| Authors: | Dr Ronan P Kelly Kwee Poo Yeo Helen B Isaac Chung-Yung J Lee Shan Hong Huang Lorraine Teng |
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| Institution: | 1. Lilly-NUS Centre for Clinical Pharmacology, Level 6, Clinical Research Centre (MD 11), National University of Singapore, 10 Medical Drive, Singapore, 117597ronan.kelly@lilly.com;3. Lilly-NUS Centre for Clinical Pharmacology, Level 6, Clinical Research Centre (MD 11), National University of Singapore, 10 Medical Drive, Singapore, 117597;4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, Singapore, 117597 |
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| Abstract: | Vitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator, possibly by increasing nitric oxide bioavailability. This study examined the antioxidant and vascular effects of a single large oral dose of vitamin C in 26 healthy human volunteers. Haemodynamic and oxidative DNA and lipid damage markers were measured for 8 h following an oral dose of 2 g vitamin C or placebo. Vitamin C had no effect on vasodilation (measured by augmentation index (mean change=0.04%, 90% CI=? 2.20% to 2.28%) or forearm blood flow (?0.19%/min (?0.68, 0.30)), in comparison to placebo) or on several markers of oxidative stress including DNA base oxidation products in blood cells, 8-hydroxy-2’-deoxyguanosine (8O HdG) in urine (0.068 (?0.009, 0.144)) or urinary or plasma total F2-isoprostanes (?0.005 ng/ml (?0.021, 0.010), ?0.153 ng/mg (?0.319, 0.014), respectively). |
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| Keywords: | Vitamin C arterial stiffness oxidative stress isoprostanes |
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