Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer,Cellular Time-keeping,Growth, Aging and Neurodegenerative Diseases |
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| Authors: | D. James Morré Dorothy M. Morré |
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| Affiliation: | 1. Department of Medicinal Chemistry and Molecular Pharmacology Hansen Life Sciences Research Building West Lafayette IN USA;2. Department of Foods and Nutrition, Stone Hall Purdue University West Lafayette IN 47907 USA |
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| Abstract: | ECTO-NOX (because of their cell surface location) proteins comprise a family of NAD(P)H oxidases of plants and animals that exhibit both oxidative and protein disulfide isomerase-like activities. The two biochemical activities, hydroquinone [NAD(P)H] oxidation and protein disulfide-thiol interchange alternate, a property unprecedented in the biochemical literature. A tumor-associated ECTO-NOX (tNOX) is cancer-specific and drug-responsive. The constitutive ECTO-NOX (CNOX) is ubiquitous and refractory to drugs. The physiological substrate for the oxidative activity appears to be hydroquinones of the plasma membrane such as reduced coenzyme Q10. ECTO-NOX proteins are growth-related and drive cell enlargement. Also indicated are roles in aging and in neurodegenerative diseases. The regular pattern of oscillations appears to be related to α-helix-β-structure transitions and serves biochemical core oscillator of the cellular biological clock. Period length is independent of temperature (temperature compensated) and synchrony is achieved through entrainment. |
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| Keywords: | Ecto-NOX |
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