High-performance liquid chromatographic determination of iobitridol in plasma, urine and bile |
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Authors: | P. Bourrinet H. Feldman A. Dencausse C. Chambon B. Bonnemain |
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Affiliation: | Laboratoire Guerbet, B.P. 50400, 95943, Roissy Charles de Gaulle cedex, France |
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Abstract: | Iobitridol is a new non-ionic, low-osmolality contrast medium for urography and angiography. We have developed a method for determining iobitridol in body fluids using high-performance liquid chromatography with ultraviolet detection. The method, which is specific and reproducible, does not require an internal standard. Determinations can be carried out in body fluids against a set of standards in ethanol. The method was validated for the quantification of iobitridol in biological samples obtained during pharmacokinetic studies. |
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