Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities |
| |
| Authors: | Jin Chunyang Manikumar G Kepler John A Cook C Edgar Allan George F Kiddoe Margaret Bhattacharjee Sheela Linton Olivia Lundeen Scott G Sui Zhihua |
| |
| Institution: | Center for Organic and Medicinal Chemistry, RTI International, PO Box 12194, Research Triangle Park, NC 27709, USA. cjin@rti.org |
| |
| Abstract: | A series of novel 11beta-aryl-4',5'-dihydrospiroestra-4,9-diene-17beta,4'-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
