Stimulation of frog ciliated cells in culture by acetylcholine and substance P. |
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Authors: | E Aiello J Kennedy C Hernandez |
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Institution: | Department of Biological Sciences, Fordham University, Bronx, NY 10458. |
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Abstract: | 1. Ciliary beat frequency in epithelial outgrowths from cultured explants of Rana pipiens palate changed markedly from second to second. 2. Acetylcholine (10(-8) to 10(-3) M) and substance P (1.35 x 10(-7) to 1.35 x 10(-5) M) increased and stabilized ciliary beat frequency. The effect of acetylcholine and part of the effect of substance P were blocked by atropine (10(-4) M). 3. Acetylcholine appears to act directly and substance P both directly and indirectly through the release of acetylcholine. |
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