Apoptotic pathways: involvement of lysosomal proteases |
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Authors: | Turk Boris Stoka Veronica Rozman-Pungercar Jerica Cirman Tina Droga-Mazovec Gabriela Oresić Kristina Turk Vito |
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Affiliation: | Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia. |
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Abstract: | Apoptosis or programmed cell death is the major mechanism used by multicellular organisms to remove infected, excessive and potentially dangerous cells. Cysteine proteases from the caspase family play a crucial role in the process. However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed. |
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