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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine
Authors:Zhou Yuefen  Webber Stephen E  Murphy Douglas E  Li Lian-Sheng  Dragovich Peter S  Tran Chinh V  Sun Zhongxiang  Ruebsam Frank  Shah Amit M  Tsan Mei  Showalter Richard E  Patel Rupal  Li Bin  Zhao Qiang  Han Qing  Hermann Thomas  Kissinger Charles R  Lebrun Laurie  Sergeeva Maria V  Kirkovsky Leo
Institution:Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.
Abstract:5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure-activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed.
Keywords:
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