The value of microparticles in detecting acute rejection episodes after liver transplantation |
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| Authors: | Mehmet Haluk Morgul Katrin Splith Christoph Leonhardt Nathanael Raschzok Anja Reutzel-Selke Rosa Bianca Schmuck |
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| Institution: | 1. Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité – Universit?tsmedizin Berlin, Berlin, Germany;2. haluk.morgul@gmail.com;4. Department of Medicine I Cardiology, Angiology and Intensive Care, General Hospital Chemnitz gGmbH, Chemnitz, Germany |
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| Abstract: | Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.Materials and Methods: MP (CD4, CD8, CD25, CD31, MHC) of 11?AR patients and 11 controls were analyzed within the first week after transplantation.Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.Discussion and Conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation. |
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| Keywords: | T cell-derived microparticles endothelial cell-derived microparticles regulatory T cells graft monitoring non-invasive marker |
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