Increased circulating endothelial microparticles in children with FMF |
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| Authors: | Sibel Yel İsmail Dursun Feyza Çetin Funda Baştuğ Sebahat Tülpar Ruhan Düşünsel |
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| Institution: | 1. Department of Pediatric Nephrology, Kayseri Education and Research Hospital, Kayseri, Turkey;2. Department of Pediatric Nephrology, Erciyes University Faculty of Medicine, Kayseri, Turkey;3. Department of Microbiology, Kayseri Education and Research Hospital, Kayseri, Turkey |
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| Abstract: | Objective: Endothelial microparticles (EMPs) are considered as markers of endothelial dysfunction. In this study, we aimed to examine whether there is endothelial dysfunction in children with familial Mediterranean fever (FMF), hypothesizing that endothelial dysfunction would be present especially with acute-phase response in the active period of the disease.Methods: This cross-sectional study included 65 FMF patients (41 attack free, 24 attack period) and 35 healthy controls. Circulating EMPs, serum amyloid A (SAA), and other inflammation markers were measured in all groups. Circulating EMPs were measured using flow cytometry. Study groups were compared for circulating EMP and inflammatory markers. The relationship between EMPs and the activation of the disease was evaluated.Results: The levels of CD144+ and CD146+ EMPs in the FMF attack period group were significantly higher than those of the control group (p?p?+ and CD146+ EMP were significantly correlated with CRP.Conclusions: Our results suggest that endothelial damage is present especially in the active period of the disease in children with FMF. The endothelial dysfunction becomes an overt parallel with inflammation. |
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| Keywords: | Endothelial dysfunction endothelial microparticle familial Mediterranean fever inflammation |
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