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miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma |
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| Authors: | Guan Sun Ying Cao Peibei Wang Hongmao Song Tongwu Bie |
| Institution: | 1. Department of Neurosurgery, The Forth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu, China;2. Department of Ear-Nose-Throat, The Second People's Hospital of Huai’An, Jiangsu, China;3. Department of Ear-Nose-Throat, The Second People's Hospital of Huai’An, Jiangsu, China;4. Department of Ear-Nose-Throat, The Second People's Hospital of Taizhou, Taizhou, Jiangsu, China |
| Abstract: | Context: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour. Objective: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC). Materials and methods: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. Results: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis. Discussion and conclusion: Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC. |
| Keywords: | miR-200b-3p oral squamous cell carcinoma diagnosis prognosis |